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According to a recent study, phototherapy did not decrease Neurodevelopmental impairments or deaths in infants weighing less than 1,000g. Although the aggressive treatment using phototherapy was effective in reducing Neurodevelopmental impairments in infants weighing only 501-751 g, death rates tended to be higher. Phototherapy is often used to decrease bilirubin levels. High levels of bilirubin can lead to hearing loss. Other treatment strategies, such as the use of tin mesoporphyrin, might be the safest and most effective strategy to address the postnatal rise in serum bilirubin levels in these tiny infants.